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Adam Clarke

tGen 22:21 Huz - He is supposed to have peopled the land of Uz or Ausitis, in Arabia Deserta, the country of Job.
Buz his brother - From this person Elihu the Buzite, one of the friends of Job, is thought to have descended.
Kemuel the father of Aram - Kamouel πατερα Συρων, the father of the Syrians, according to the Septuagint. Probably the Kamiletes, a Syrian tribe to the westward of the Euphrates are meant; they are mentioned by Strabo. Genesis 22:23

(KAD) Carl Friedrich Keil and Franz Delitzsch

tGen 22:20 Descendants of Nahor. - With the sacrifice of Isaac the test of Abraham's faith was now complete, and the purpose of his divine calling answered: the history of his life, therefore, now hastens to its termination. But first of all there is introduced quite appropriately an account of the family of his brother Nahor, which is so far in place immediately after the story of the sacrifice of Isaac, that it prepares the way for the history of the marriage of the heir of the promise. The connection is pointed out in Gen 22:20, as compared with Gen 11:29, in the expression, "she also." Nahor, like Ishmael and Jacob, had twelve sons, eight by his wife Milcah and four by his concubine; whereas Jacob had his by two wives and two maids, and Ishmael apparently all by one wife. This difference with regard to the mothers proves that the agreement as to the number twelve rests upon a good historical tradition, and is no product of a later myth, which traced to Nahor the same number of tribes as to Ishmael and Jacob. For it is a perfectly groundless assertion or assumption, that Nahor's twelve sons were the fathers of as many tribes. There are only a few names, of which it is probable that their bearers were the founders of tribes of the same name. On Uz, see Gen 10:23. Buz is mentioned in Jer 25:23 along with Dedan and Tema as an Arabian tribe; and Elihu was a Buzite of the family of Ram (Job 32:2). Kemuel, the father of Aram, was not the founder of the Aramaeans, but the forefather of the family of Ram, to which the Buzite Elihu belonged, - Aram being written for Ram, like Arammim in Kg2 8:29 for Rammim in Ch2 22:5. Chesed again was not the father of the Chasdim (Chaldeans), for they were older than Chesed; at the most he was only the founder of one branch of the Chasdim, possibly those who stole Job's camels (Knobel; vid., Job 1:17). Of the remaining names, Bethuel was not the founder of a tribe, but the father of Laban and Rebekah (Gen 25:20). The others are never met with again, with the exception of Maachach, from whom probably the Maachites (Deu 3:14; Jos 12:5) in the land of Maacah, a small Arabian kingdom in the time of David (Sa2 10:6, Sa2 10:8; Ch1 19:6), derived their origin and name; though Maachah frequently occurs as the name of a person (Kg1 2:39; Ch1 11:43; Ch1 27:16). Next: Genesis Chapter 23

John Gill

tGen 22:21
Huz his firstborn, and Buz his brother,.... The first of these gave name to the land of Uz, where Job dwelt, and who seems to be a descendant of this man, Job 1:1; and from whom sprung the Ausitae of Ptolemy (p), who dwelt near Babylon and by the Euphrates. The latter, was the father of the Buzites, of which family Elihu was, that interposed between Job and his friends, Job 32:2, and Kemuel the father of Aram; not that Aram from whom the Syrians are denominated Arameans, he was the son of Shem, Gen 10:22, but one who perhaps was so called from dwelling among them, as Jacob is, called a Syrian, Deu 26:5, or he had this name given him in memory and honour of the more ancient Aram: from this Kemuel might come the Camelites, of which there were two sorts mentioned by Strabo (q), and who dwelt to the right of the river Euphrates, about three days' journey from it. (p) Geograph. l. 5. c. 19. (q) Geograph. l. 16. p. 515. Genesis 22:22